Experience & Research

Dr. Mariano Palena’s Journey in Endovascular Innovation

Dr. Mariano Palena is an internationally recognized Interventional Radiologist with a strong focus on endovascular treatment for limb salvage, particularly in patients with Chronic Limb-Threatening Ischemia (CLTI) and diabetic foot complications. His work combines clinical excellence, research, and education to advance minimally invasive solutions that help patients avoid amputation whenever possible.

Professional Background

After graduating in Medicine and completing his specialization in Radiology at the University of Bologna (Italy), Dr. Mariano Palena dedicated his career to advancing endovascular solutions for patients with severe peripheral artery disease and limb-threatening conditions.

He led the Endovascular Surgery Unit at GVM Maria Cecilia Hospital (2019–2022), where he managed complex cases of Chronic Limb-Threatening Ischemia (CLTI) and diabetic foot revascularization.
Dr. Palena has also maintained a long-standing collaboration with Policlinico Abano Terme (since 2010).

Current Clinical Appointments:

Policlinico Abano Terme, Padua – Italy
Quirónsalud Hospital, Marbella – Spain
MHAT St. Karidad Hospital, Plovdiv – Bulgaria
UNHATEM “N.I. Pirogov”, Sofia – Bulgaria

Leadership in Education

Beyond his clinical practice, Dr. Palena is deeply committed to medical education and knowledge sharing:

Co-Founder and Course Director of CLI-Courses – the leading international meeting on CLTI and diabetic foot revascularization, entirely built around live cases.
Founder of DREAM Vascular (Diabetic foot REvascularization & reconstruction Advanced Meeting) – a new educational event launching in March 2026, focused on multidisciplinary strategies for limb salvage.
Frequent speaker, live case operator, and faculty member at major international vascular congresses.
Mentor for physicians worldwide through fellowship programs and hands-on training.

Research & Publications

Drug-coated balloon angioplasty for the management of recurring infrapopliteal disease in diabetic patients with critical limb ischemia

Palena LM, Diaz-Sandoval LJ, Gomez-Jaballera E, Peypoch-Perez O, Sultato E, Brigato C

Read abstract

A multicenter prospective observational study appraising the effectiveness of the Supera stent after subintimal recanalization of femoro-popliteal artery occlusion: The SUPERSUB II study

Palena LM, Isernia G, Parlani G, Veroux P, Ficarelli I, Frascheri A, et al.

Read abstract

Below-the-Ankle Orbital Atherectomy in Chronic Limb-Threatening Ischemia Patients as a Bailout Strategy for Limb Salvage: Early Clinical Experience

Palena LM, Saad PF, Piccolo E, Gabellini T, Baldazzi G, Ciofani L, et al.

Read abstract

Search on PubMed

Commitment to Innovation

Dr. Palena is at the forefront of innovation in endovascular therapy.

His mission is clear: to expand the possibilities of limb preservation through cutting-edge, minimally invasive solutions—always grounded in real-world clinical evidence.

Learn More about Treatments or Get in Touch

Dr. Mariano Palena combines clinical expertise, research, and education to advance limb salvage worldwide. Explore treatment options or get in touch for more information.

Contact Dr. Palena

Treatment options